I have CS50/Windows 10 problem but I've been able to resolve the first error by removing the CS50 appliance and re-importing then effecting the network changes (IP/Subnet) under settings/preferences.
However, it still says invalid settings detected - No bridge network adapter is currently selected. I have a feeling it's a problem with the Name - VirtualBox Host-only Ethernet Adapter #2. It shouldn;t have #2. I don't know how to get rid of that or solve the problem altogether. Help